Dymecki Lab Publications

ORIGINAL ARTICLES (reverse chronology)

Dosumu-Johnson R.T., Corcoran A.E., Chang YJ., Nattie, E., Dymecki S. Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery. eLife, 2018 Oct. 23.
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Weinhard L., Neniskyte U., Vadisiute A., di Bartolomei G., Aygun N., Riviere L., Dymecki S., Gross C.
Sexual dimorphism of microglia and synapses during mouse postnatal development. Developmental Neurobiology, 2018 Jan. 4.
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Hennessy M.L., Corcoran A.E., Brust R.D., Chang Y.J., Nattie E.E., Dymecki S.M.
Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex. Journal of Neuroscience, 2017 Feb. 15;37(7); 1807-1819.
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Abraira Kuehn E.D., Chirla A.M., Springel, M.W., Toliver A.A., Zimmerman A.L., Orefice L.L., Boyle K.A., Bai L., Song B.J., Bashista K.A., O'Neill T.G., Zhuo J., Tsan C., Hoynoski J., Rutlin M., Kus L., Niederkofler V., Watanabe M., Dymecki S.M., Nelson S.B., Heintz N., Hughes D.I., Ginty D.D.
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell, 2017 Jan. 12: Vol. 168, 295-310
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Niederkofler V., Asher T.E., Okaty B.W., Rood BD., Narayan A., Hwa LS., Beck S.G., Miczek K.A., Dymecki S.M.
Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior. Cell Reports, 2016 Nov 15:17(8): 1934-1949
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Barrett, K.T., Dosumu-Johnson, R.T., Daubenspeck, J.A., Brust, R.D., Kreouzis, V., Kim, J.C., Li, A., Dymecki, S.M., Nattie, E.E.
Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development.
Journal of Neuroscience, 2016 April 6, 36(14): 3934-3953.
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Okaty B.W., Freret M.E., Rood B.D., Brust R.D., Hennessy M.L., deBairos D., Kim J.C., Cook M.N., Dymecki S.M.
Multi-Scale Molecular Deconstruction of the Serotonin Neuron System.
Neuron, 2015 Nov 18;88(4): 774-91.

Teissier, A., Chemiakine, A., Inbar, B., Bagchi, Sneha, Ray, R. S., Palmiter, R.D., Dymecki, S.M., Moore, H., Ansorge, M.S.
Activity of Raphe Serotonergic Neurons Controls Emotional Behaviors.
Cell Reports, 2015.

Britz O., Zhang J., Grossmann K.S., Dyck J., Kim, J.C., Dymecki S.M., Gosgnach S., M. Goulding
A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements.
eLife, 2015.

Niederkofler V, Asher TE, Dymecki SM.
Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood.
ACS Chem Neurosci, 2015 July 15;6(7): 1055-70.

Konstantinos E. H., Takeuchi L.M., Saur D., Seidler B., Dymecki S.M, Mai, J., White I.A., Balkan W., Kanashiro-Takeuchi R.M., Schally A V., J.M. Hare
cKit+ cardiac progenitors of neural crest origin.
Proceedings of the National Academy of Sciences, 2015.

Brust R.D., Corcoran A.E., Richerson G.B, Nattie E., Dymecki S.M. Functional and Developmental Identification of a Molecular Subtype of Brain Serotonergic Neuron Specialized to Regulate Breathing Dynamics.
Cell Reports, 2014.

I. Espinoza-Medina, E. Outin, C.A. Picard, Z. Chettouh, S. Dymecki, G.G. Consalez, E. Coppola, J.-F. Brunet.
Parasympathetic ganglia derive from Schwann cell precursors.
Science, 2014.

Lehtinen M.K., Bjornsson C.S., Dymecki S.M., Gilbertson R.J., Holtzman D.M., Monuki E.S.
The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy.
Journal of Neuroscience, 2013.

Heimer-McGinn, V., Murphy, A. C. H., Kim, J. C., Dymecki, S. M., & Young, P. W.
Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo.
Neuroscience letters, 2013.

Hirsch, M.-R., d'Autreaux, F., Dymecki, S. M., Brunet, J.-F., & Goridis, C.
A Phox2b FLPo transgenic mouse line suitable for intersectional genetics.
Genesis, 2013 51(7):506-14.

Massey, C. A., Kim, G., Corcoran, A. E., Haynes, R. L., Paterson, D. S., Cummings, K. J., et al.
Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice.
Journal of neurochemistry, 2013 126(6):749 - 757.

Ray, R. S., Corcoran, A. E., Brust, R. D., Soriano, L., Nattie, E. E., & Dymecki, S. M.
Egr2-neurons control the adult respiratory response to hypercapnia.
Brain research, 2012 1511:115-25.

Engleka, K.A., Manderfield, L.J., Brust, R. D., Li, L., Cohen, A., Dymecki, S.M., Epstein, J.A.
Islet1 derivatives in the heart are of both neural crest and second heart field origin.
Circulation Research, 2012 10(7):922-6.

Bang, S.J., Jensen, P., Dymecki, S.M., and Commons, K.G.
Projections and interconnections of genetically defined serotonin neurons in mice.
European Journal of Neuroscience 2012 35(1):85-96.

Ray R.S., Corcoran A.E., Brust R.D., Kim J.C., Richerson G.B., Nattie E. and Dymecki S.M.
Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition.
Science. 2011 July 29;333(6042):637-642.

Nielsen C.M., Dymecki S.M.
Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus.
Developmental Biology. 2010 Apr 15;340(2):430-7.

Kim J.C., Cook M.N., Carey M.R., Shen C., Regehr W.G., Dymecki S.M.
Linking genetically defined neurons to behavior through a broadly applicable silencing allele.
Neuron 2009 Aug 13;63(3):305-15.

Dipietrantonio H.J., Dymecki S.M.
Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem.
Neuroscience 2009 Sep 1;162(3):560-73.

Kim J.C., Dymecki S.M.
Genetic fate-mapping approaches: new means to explore the embryonic origins of the cochlear nucleus.
Methods in Moleclar Biology 2009;493:65-85.

Kan L., Liu Y., McGuire T.L., Palila Berger D.M., Awatramani R.B., Dymecki S.M., Kessler J.A.
Dysregulation of Local Stem/Progenitor Cells as a Common Cellular Mechanism for Heterotopic Ossification.
Stem Cells 2009 Jan;27(1):150-6.

Jensen P., Farago A.F., Awatramani R.B., Scott M.M., Deneris E.S., Dymecki S.M.
Redefining the serotonergic system by genetic lineage.
Nature Neuroscience 2008 11(4):417-9.

Hunter, N.L., Dymecki, S.M.
Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus.
Development 2007 134:3449-60.

Farago, A.F., Awatramani, R., and Dymecki, S. M.,
Assembly of the Brainstem Cochlear Nuclear Complex is Revealed by Intersectional and Subtractive Genetic Fate Maps.
Neuron 2006 50:205-218.

Landsberg, R.L., Awatramani, R. B., Hunter, N.L., Farago, A.F., DiPietrantoio, H.J., and Dymecki, S.M.
Hindbrain Rhombic Lip is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6.
Neuron 2005 48:933-947.

Subject of News and Views:
Pearse R.V. and Tabin, C.J. (2006) Twists of fate in the brain.
Nature 439:404-405.

Hunter, N.L.^, Hikasa, H.^, Dymecki, S.#, and Sokol, S#.
Vertebrate homolgues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements.
Developmental Dynamics 2006; 235:279-284 (^ and # denote equal contribution).

Hunter, N.L, Awatramani, R, Farley, F., and Dymecki, S.
Ligand-activated Flpe for temporal regulation of gene modifications.
Genesis 2005 41:99-109.

Austin, C.P et al.
The Knockout Mouse Project: A comprehensive plan for placing knockouts of all mouse genes and associated phenotype data into the public domain.
Nature Genetics 2004; 36:921-924.

Awatramani, R., Soriano, P., Rodriguez, C., Mai, J., and Dymecki, S.
Cryptic Boundaries in Roof Plate and Choroid Plexus Revealed by Intersectional Gene Activation.
Nature Genetics 2003; 35:70-75.

Awatramani R., Soriano P., Mai J., and Dymecki S.
An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus.
Nature Genetics 2001;29:257-259.

Rodriguez, C. I. and Dymecki, S.
Origin of the precerebellar system.
Neuron 27: 475-486. (associated Preview - Rakic, P., Illegal Immigrations.(2000) Neuron 27: 409-410)

Farley, F., Soriano, P. Stefan, L.,and Dymecki, S.
Widespread recombinase expression using FLPeR (flipper) mice.
Genesis 2000 28:106-110

Rodriguez, C.I., Buchholz, F., Galloway, J., Sequerra, R., Kasper, J., Ayala, R., Stewart, A.F., and Dymecki, S.
High efficiency deleter mice demonstrate that FLPe provides an alternative to Cre-loxP for in vivo genetic engineering.
Nature Genetics 2000 25: 139-140.

Baur, S., Mai, J. and Dymecki, S.
Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity.
Development 2000 127 (3)605-619.

Dymecki, S. and Tomasiewicz, H.
Using Flp recombinase to characterize expansion of Wnt1- expressing neural progenitors in the mouse.
Developmental Biology (1998) 201: 57-65.

Dymecki, S.
Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996 93: 6191-6196.

Dymecki, S.
A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site- specific recombination.
Gene 1996 171:197-201.

Klages, S., Adam, A., Eiseman, E., Fargnoll, J., Dymecki, S.M., Desiderio, S.V., and Bolen, J.
Molecular Cloning and Analysis of cDNA Encoding the Murine c-yes Tyrosine Protein Kinase.
Oncogene 1993 8:713-719.

Dymecki, S., Zwollo, P., Zeller, K., Kuhajda, F.P., and Desiderio, S.V.
Structure and Developmental Regulation of the B-Lymphoid Tyrosine Kinase Gene BLK.
J. Biol. Chem. 1992 267: 4815-4823.

Wilson, R.B., Kiledjian, M., Shen, C., Benezra, R., Zwollo, P., Dymecki, S.M., Desiderio, S.V., and Kadesch, T.
Repression of Immunoglobulin Enhancers by the Helix-Loop-Helix Protein Id: Implications for B-Lymphoid-Cell Development.
Molecular and Cellular Biology 1991 11: 6185-6191.

Kozak, C., Dymecki, S., Niederhuber, J., and Desiderio, S.
Genetic Mapping of the Gene for a Novel Tyrosine Kinase, Blkblk, to Mouse chromosome 14.
Genomics 1991 9: 762-764.

Dymecki S., Niederhuber J., Desiderio S.
Specific Expression of a Tyrosine Kinase Gene blk, in B Lymphoid Cells. Science 1990 247: 332-336.

Dymecki, S., Black, J., Nord, S., Baranowski, T., and Brighton, C.T.
Medullary Osteogenesis with Platinum Cathodes.
Journal of Orthopaedic Research 1985 3:125-136.

REVIEWS (peer-reviewed)

Niderkofler V., Asher T.E., Dymecki S.M.
Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood.
ACS Chemical Neuroscience, 2015.

Ray R.S., Dymecki S.M.
Rautenlippe Redux-toward a unified view of the precerebellar rhombic lip.
Curr Opin Cell Biol. 2009 Oct 31

Kinney H.C., Richerson G.B., Dymecki S.M., Darnall R.A., Nattie E.E.
The brainstem and serotonin in the sudden infant death syndrome.
Annu Rev Pathol 2009;4:517-50.

Dymecki, S.M. and Kim, J.C.
Molecular neuroanatomy's "Three Gs": a primer.
Neuron 2007 54:17-34.

Branda, C.S. and Dymecki, S.M.
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.
Developmental Cell 2004 6:7-28.


Jensen P, Dymecki SM.
Essentials of recombinase-based genetic fate mapping in mice.
Methods Mol Biol. 2014;1092:437-54.
PubMed PMID: 24318835; PubMed Central PMCID: PMC4035813.

Dymecki S.M., Ray R.S., Kim J.C.
Mapping cell fate and function using recombinase-based intersectional strategies.
In: J. Abelson AND M. Simon. editors. Methods in Enzymology. 2010;477:183-213

Kim J.C., Dymecki S.M.
Genetic fate-mapping approaches: new means to explore the embryonic origins of the cochlear nucleus.
In: J. Walker, editor. Methods in Moleclar Biology 2009;493:65-85.

Dymecki S.M., Rodriguez C.I., and Awatramani R.
Switching on lineage tracers using site-specific recombination.
In: K. Turksen, editor. Embryonic Stem Cells: Methods and Protocols. Humana Press; 2002. p.309-334.

Dymecki S.
Site-specific recombination in cells and mice.
In: A. Joyner, editor. Gene targeting: a practical approach. Oxford University Press; 2000. p. 37-99.

Desiderio S.V. and Dymecki S.M.
Molecular Mechanisms of B-Cell Activation.
In: A. Levinson and Y. Paterson, editors. Molecular Biology of the Allergic Immune Response. 1992