MOST RECENT PAPERS
Senft, R.A. and Dymecki, S.M. Neuronal pericellular baskets: neurotransmitter convergence and regulation of network excitability. Trends in Neurosciences, In press.
Senft R.A., Freret M.E., Sturrock N., Dymecki S.M.
Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
Journal of Neuroscience, 2021 March 24.
Lyon K.A., Rood B.D., Senft R.A., Goodrich L.V., Dymecki S.M.
Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior.
eNeuro, 2020 November 19.
Okaty B.W., Sturrock N., Escobedo Lozoya Y., Chang YJ., Senft R.A., Lyon K.A., Alekseyenko O.V., Dymecki S.M.
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons.
eLife, 2020 June 22.
Baskin B.M., Mai J., Dymecki S.M., Kantak K.M.
Cocaine reward and memory after chemogenetic inhibition of distinct serotonin neuron subtypes in mice.
Psychopharmacology, 2020 May 18.
Alekseyenko O.V., Chan Y-B, Okaty B.W, Chang YJ, Dymecki S.M., Kravitz E.A.
Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.
Cell Reports, 2019 June 20
Okaty B.W., Commons, K.G., Dymecki S.M.
Embracing diversity in the 5-HT neuronal system.
Nature Reviews Neuroscience, 2019 April 4
Abstract
Lunde A., Okaty B.W., Dymecki S.M., Glover, J.C.
Molecular profiling defines evolutionarily conserved transcription factor
signatures of major vestibulospinal neuron groups.
eNeuro, 2019 Feb 1.
Zhou Q.G., Nemes A.D., Lee D., Ro E.J., Zhang J., Nowacki A.S., Dymecki S.M., Najm I.M., Suh H.
Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits.
The Journal of Clinical Investigation, 2018 Dec 3.
Dosumu-Johnson R.T., Corcoran A.E., Chang YJ., Nattie, E., Dymecki S.
Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery.
eLife, 2018 Oct. 23.
Weinhard L., Neniskyte U., Vadisiute A., di Bartolomei G., Aygun N., Riviere L., Dymecki S.M, Gross C.
Sexual dimorphism of microglia and synapses during mouse postnatal development.
Developmental Neurobiology, 2018 Jan. 4.
Hennessy, M.L., Corcoran, A.E., Brust, R.D., Chang Y.J., Nattie, E.E., Dymecki, S.M.
Activity of Tachykinin 1-expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex. Journal of Neuroscience, 2017. 37:1807-1819.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD.
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Cell. 2017 Jan 12;168(1-2):295-310.e19.
Santiago-Sim T, Fang X, Hennessy ML, Nalbach SV, DePalma SR, Lee MS, Greenway SC, McDonough B, Hergenroeder GW, Patek KJ, Colosimo SM, Qualmann KJ, Hagan JP, Milewicz DM, MacRae CA, Dymecki SM, Seidman CE, Seidman JG, Kim DH.
THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.
Stroke. 2016 Dec;47(12):3005-3013.
Niederkofler V., Asher T.E., Okaty B.W., Rood B.D., Narayan A., Hwa LS., Beck S.G., Miczek K.A., Dymecki S.M.
Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior.
Cell Reports, 2016 Nov 15;17(8): 1934-1949
Barrett K.T, Dosumu-Johnson R.T., Daubenspeck J.A., Brust R.D., Kreouzis V., Kim J.C., Li A., Dymecki S.M., Nattie E.E.
Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development.
J Neurosci. 2016 Apr 6;36(14):3943-53
Teissier A., Chemiakine A., Inbar B., Bagchi S., Ray R.S., Palmiter R.D., Dymecki S.M., Moore H., Ansorge M.S.
Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors.
Cell Reports, 2015 Dec 1; 13(9):1965-76
Okaty B.W., Freret M.E., Rood B.D., Brust R.D., Hennessy M.L., deBairos D., Kim J.C., Cook M.N., Dymecki S.M.
Multi-Scale Molecular Deconstruction of the Serotonin Neuron System.
Neuron, 2015 Nov 18; 88(4): 774-91.
Britz O., Zhang J., Grossmann K.S., Dyck J., Kim, J.C., Dymecki S.M., Gosgnach S., M. Goulding
A genetically defined asymmetry underlies th einhibitory control of flexor-extensor locomotor movements.
eLife, 2015.
Niederkofler V, Asher TE, Dymecki SM.
Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood.
ACS Chem Neurosci, 2015 July 15;6(7): 1055-70.
Konstantinos E. H., Takeuchi L.M., Saur D., Seidler B., Dymecki S.M, Mai, J., White I.A., Balkan W., Kanashiro-Takeuchi R.M., Schally A V., J.M. Hare
cKit+ cardiac progenitors of neural crest origin.
Proceedings of the National Academy of Sciences, 2015.
Brust R.D., Corcoran A.E., Richerson G.B, Nattie E., Dymecki S.M.
Functional and Developmental Identification of a Molecular Subtype of Brain Serotonergic Neuron Specialized to Regulate Breathing Dynamics.
Cell Reports, 2014.
I. Espinoza-Medina, E. Outin, C.A. Picard, Z. Chettouh, S. Dymecki, G.G. Consalez, E. Coppola, J.-F. Brunet.
Parasympathetic ganglia derive from Schwann cell precursors.
Science, 2014.
Jensen P, Dymecki SM.
Essentials of recombinase-based genetic fate mapping in mice.
Methods Mol Biol. 2014;1092:437-54.
Lehtinen M.K., Bjornsson C.S., Dymecki S.M., Gilbertson R.J., Holtzman D.M., Monuki E.S.
The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy.
Journal of Neuroscience, 2013.
Heimer-McGinn, V., Murphy, A. C. H., Kim, J. C., Dymecki, S. M., & Young, P. W.
Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo.
Neuroscience letters, 2013.
Hirsch, M.-R., d'Autreaux, F., Dymecki, S. M., Brunet, J.-F., & Goridis, C.
A Phox2b FLPo transgenic mouse line suitable for intersectional genetics.
Genesis, 2013 51(7):506-14.
Massey, C. A., Kim, G., Corcoran, A. E., Haynes, R. L., Paterson, D. S., Cummings, K. J., et al.
Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice.
Journal of neurochemistry, 2013 126(6):749 - 757.
Ray, R. S., Corcoran, A. E., Brust, R. D., Soriano, L., Nattie, E. E., & Dymecki, S. M.
Egr2-neurons control the adult respiratory response to hypercapnia.
Brain research, 2012 1511:115-25.
Engleka, K.A., Manderfield, L.J., Brust, R. D., Li, L., Cohen, A., Dymecki, S.M., Epstein, J.A.
Islet1 derivatives in the heart are of both neural crest and second heart field origin.
Circulation Research, 2012 10(7):922-6.
Bang, S.J., Jensen, P., Dymecki, S.M., and Commons, K.G.
Projections and interconnections of genetically defined serotonin neurons in mice.
European Journal of Neuroscience 2012 35(1):85-96.
Ray R.S., Corcoran A.E., Brust R.D., Kim J.C., Richerson G.B., Nattie E. and Dymecki S.M.
Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition.
Science. 2011 July 29;333(6042):637-642.
Dymecki SM, Ray RS, Kim JC.
Mapping cell fate and function using recombinase-based intersectional strategies.
Methods Enzymol. 2010;477:183-213.
Nielsen C.M., Dymecki S.M.
Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus.
Developmental Biology. 2010 Apr 15;340(2):430-7.
Ray RS, Dymecki SM.
Rautenlippe Redux -- toward a unified view of the precerebellar rhombic lip.
Curr Opin Cell Biol. 2009 Dec;21(6):741-7.
Kim J.C., Cook M.N., Carey M.R., Shen C., Regehr W.G., Dymecki S.M.
Linking genetically defined neurons to behavior through a broadly applicable silencing allele.
Neuron, 2009 Aug 13;63(3):305-15.
Kinney HC, Richerson GB, Dymecki SM, Darnall RA, Nattie EE.
The brainstem and serotonin in the sudden infant death syndrome.
Annu Rev Pathol. 2009;4:517-50
Dipietrantonio H.J., Dymecki S.M.
Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem.
Neuroscience, 2009 Sep 1;162(3):560-73.
Kim J.C., Dymecki S.M.
Genetic fate-mapping approaches: new means to explore the embryonic origins of the cochlear nucleus.
Methods in Molecular Biology, 2009;493:65-85.
Kan L., Liu Y., McGuire T.L., Palila Berger D.M., Awatramani R.B., Dymecki S.M., Kessler J.A.
Dysregulation of Local Stem/Progenitor Cells as a Common Cellular Mechanism for Heterotopic Ossification.
Stem Cells 2009 Jan;27(1):150-6.
Jensen P., Farago A.F., Awatramani R.B., Scott M.M., Deneris E.S., Dymecki S.M.
Redefining the serotonergic system by genetic lineage.
Nature Neuroscience, 2008 11(4):417-9.
Hunter, N.L., Dymecki, S.M.
Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus.
Development, 2007 134:3449-60.
Molecular neuroanatomy's "Three Gs": a primer.
Farago, A.F., Awatramani, R., and Dymecki, S. M.,
Assembly of the Brainstem Cochlear Nuclear Complex is Revealed by Intersectional and Subtractive Genetic Fate Maps.
Neuron, 2006 50:205-218.
Landsberg, R.L., Awatramani, R. B., Hunter, N.L., Farago, A.F., DiPietrantoio, H.J., and Dymecki, S.M.
Hindbrain Rhombic Lip is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6.
Neuron 2005 48:933-947.
Pearse R.V. and Tabin, C.J. (2006)
Twists of fate in the brain.
Nature, 439:404-405.
Hunter, N.L., Hikasa, H., Dymecki, S.M., and Sokol, S.
Vertebrate homolgues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements.
Developmental Dynamics, 2006; 235:279-284 (^ and # denote equal contribution).
Hunter, N.L, Awatramani, R, Farley, F., and Dymecki, S.
Ligand-activated Flpe for temporal regulation of gene modifications.
Genesis, 2005 41:99-109.
Austin, C.P et al.
The Knockout Mouse Project: A comprehensive plan for placing knockouts of all mouse genes and associated phenotype data into the public domain.
Nature Genetics, 2004; 36:921-924.
Awatramani, R., Soriano, P., Rodriguez, C., Mai, J., and Dymecki, S.
Cryptic Boundaries in Roof Plate and Choroid Plexus Revealed by Intersectional Gene Activation.
Nature Genetics, 2003; 35:70-75.
Awatramani R., Soriano P., Mai J., and Dymecki S.
An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus.
Nature Genetics, 2001;29:257-259.
Rodriguez, C. I. and Dymecki, S.
Origin of the precerebellar system.
Neuron 27: 475-486. (associated Preview - Rakic, P., Illegal Immigrations.(2000) Neuron 27: 409-410)
Farley, F., Soriano, P. Stefan, L.,and Dymecki, S.
Widespread recombinase expression using FLPeR (flipper) mice.
Genesis 2000 28:106-110
Rodriguez, C.I., Buchholz, F., Galloway, J., Sequerra, R., Kasper, J., Ayala, R., Stewart, A.F., and Dymecki, S.
High efficiency deleter mice demonstrate that FLPe provides an alternative to Cre-loxP for in vivo genetic engineering.
Nature Genetics 2000 25: 139-140.
Baur, S., Mai, J. and Dymecki, S.
Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity.
Development 2000 127 (3)605-619.
Dymecki, S. and Tomasiewicz, H.
Using Flp recombinase to characterize expansion of Wnt1- expressing neural progenitors in the mouse.
Developmental Biology (1998) 201: 57-65.
Dymecki, S.
Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America, 1996 93: 6191-6196.
Dymecki, S.
A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site- specific recombination.
Gene, 1996 171:197-201.
Klages, S., Adam, A., Eiseman, E., Fargnoll, J., Dymecki, S.M., Desiderio, S.V., and Bolen, J.
Molecular Cloning and Analysis of cDNA Encoding the Murine c-yes Tyrosine Protein Kinase.
Oncogene, 1993 8:713-719.
Dymecki, S., Zwollo, P., Zeller, K., Kuhajda, F.P., and Desiderio, S.V.
Structure and Developmental Regulation of the B-Lymphoid Tyrosine Kinase Gene BLK.
J. Biol. Chem. 1992 267: 4815-4823.
Wilson, R.B., Kiledjian, M., Shen, C., Benezra, R., Zwollo, P., Dymecki, S.M., Desiderio, S.V., and Kadesch, T.
Repression of Immunoglobulin Enhancers by the Helix-Loop-Helix Protein Id: Implications for B-Lymphoid-Cell Development.
Molecular and Cellular Biology, 1991 11: 6185-6191.
Kozak, C., Dymecki, S., Niederhuber, J., and Desiderio, S.
Genetic Mapping of the Gene for a Novel Tyrosine Kinase, Blkblk, to Mouse chromosome 14.
Genomics, 1991 9: 762-764.
Dymecki S., Niederhuber J., Desiderio S.
Specific Expression of a Tyrosine Kinase Gene blk, in B Lymphoid Cells.
Science, 1990 247: 332-336.
Dymecki, S., Black, J., Nord, S., Baranowski, T., and Brighton, C.T.
Medullary Osteogenesis with Platinum Cathodes.
Journal of Orthopaedic Research, 1985 3:125-136.
RECENTLY FEATURED
Multi-Scale Molecular Deconstruction of the Serotonin Neuron System
Okaty B.W., Freret M.E., Rood B.D., Brust R.D., Hennessy M.L., deBairos D., Kim J.C., Cook M.N., Dymecki S.M.
Neuron magazine cover design by Mallory Rice,
cover idea by Payne Freret
What Causes SIDS?
New York Times, https://parenting.nytimes.com/baby/what-causes-sids
Article by Carrie Arnold, Illustration by Jun Cen
May 24, 2019
REVIEWS (Peer-Reviewed)
Okaty B.W., Commons, K.G., Dymecki S.M.
Embracing diversity in the 5-HT neuronal system.
Nature Reviews Neuroscience, 2019 April 4
Niderkofler V., Asher T.E., Dymecki S.M.
Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood.
ACS Chemical Neuroscience, 2015.
Ray R.S., Dymecki S.M.
Rautenlippe Redux-toward a unified view of the precerebellar rhombic lip.
Curr Opin Cell Biol. 2009 Oct 31
Kinney H.C., Richerson G.B., Dymecki S.M., Darnall R.A., Nattie E.E.
The brainstem and serotonin in the sudden infant death syndrome.
Annu Rev Pathol 2009;4:517-50.
Dymecki, S.M. and Kim, J.C.
Molecular neuroanatomy's "Three Gs": a primer.
Neuron 2007 54:17-34.
Branda, C.S. and Dymecki, S.M.
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.
Developmental Cell 2004 6:7-28.
Li A., Darnall R.A, Dymecki S, Leiter J.C.
Animal Models: Illuminating the Pathogenesis of Sudden Infant Death Syndrome.
In: Duncan JR, Byard RW, editors. SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future. Adelaide (AU): University of Adelaide Press; 2018 May. Chapter 33.
ensen P, Dymecki SM.
Essentials of recombinase-based genetic fate mapping in mice.
Methods Mol Biol. 2014;1092:437-54.
PubMed PMID: 24318835; PubMed Central PMCID: PMC4035813.
Branda, C.S. and Dymecki, S.M.
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.
Developmental Cell 2004 6:7-28.
Kim J.C., Dymecki S.M.
Genetic fate-mapping approaches: new means to explore the embryonic origins of the cochlear nucleus.
In: J. Walker, editor. Methods in Moleclar Biology 2009;493:65-85.
Dymecki S.M., Rodriguez C.I., and Awatramani R.
Switching on lineage tracers using site-specific recombination.
In: K. Turksen, editor. Embryonic Stem Cells: Methods and Protocols. Humana Press; 2002. p.309-334.
Dymecki S.
Site-specific recombination in cells and mice.
In: A. Joyner, editor. Gene targeting: a practical approach. Oxford University Press; 2000. p. 37-99.
Desiderio S.V. and Dymecki S.M.
Molecular Mechanisms of B-Cell Activation.
In: A. Levinson and Y. Paterson, editors. Molecular Biology of the Allergic Immune Response. 1992
BOOK CHAPTERS
